101 research outputs found

    An ontological perspective on thematic roles

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    Collaborative Semantic Tables

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    Abstract. The scenario defined by current Web architectures and paradigms (such as Cloud Computing), poses challenges and opportunities to users. On the one hand, they have to manage huge amounts of digital resources handled by different applications in spite of their possibly related content; on the other hand, they are enabled to share knowledge and participate to content creation. The interaction of these two aspects provided a great impulse to collaborative resource management: in this paper we present T++, an environment that ex-ploits semantic knowledge about digital resources in order to face these chal-lenges, by providing an integrated and smart management of heterogeneous in-formation objects

    GO! geographical ontology

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    GO! (Geographical Ontology) ontology has been developed by Claudia Corcione, Paola De Caro and Silvia naro, with the collaboration of Diego Magro, Timothy Tambassi and Maurizio Lana for the research project \u201cGeolat \u2013 geography for Latin literature\u201d. It describes the geographical locations, with a particular attention to the description of the Ancient World, especially to give the opportunity of having a link between the places mentioned in the texts, especially ancient, and their identification and correspondence with contemporary ones. For classical scholars this correspondence of ancient / contemporary modelling is of undisputed interest, both for the study of the habits of the most ancient peoples, and for the most various themes of literary interest. Through ontologies you can build maps of the ancient world and compare them to contemporary ones, annotate historical, geographical, cultural details connected to the place, indicate in which ancient text the place is mentioned and as which author discloses the details. These are just some ideas for research that can be developed, but the scenario that opens through these connections will be much larger. The GO! modules contain numerous classes and relations and differ in the specific entities defined in them, and are connected by a Top Level ontology - GO TOP ( http://purl.org/geolit/GO-TOP ): \u2022 an ontology that describes the physical and natural places ( http://purl.org/geolit/GO-PHY ) \u2022 an anthropic ontology, in which are specified all administrative bodies and artifacts created by human activity ( http://purl.org/geolit/GO-HUM )an \u2022 an ontology for the ancient world, which describes the specific aspects ( http://purl.org/geolit/GO-FAR ), where FAR means For Ancient Resources. The GO! ontology serves as an information base for the platform of the project GeoLat. The GO! modelling choices took into account the needs which the ontology must meet, allowing to add a range of additional information about the geographical place, through the inclusion of ad hoc relationships, in particular it is possible to express: \u2022 the correspondence with the places listed by Pleiades (historical online gazetteer http://pleiades.stoa.org/) \u2022 the physical and cultural characteristics shown in the Barrington Atlas \u2022 the source where the ancient place is mentioned (with philological reference) \u2022 the geographical coordinates of corresponding contemporary sites \u2022 a description of historical events (wars, defeats ...) \u2022 the changes of the place (e.g. a village which becomes a city) \u2022 the hypotesized location of imaginary places (such as Hades) \u2022 the physical and geopolitical description of the place These are only some of the potentialities of the GO! ontology, which incorporates some standard ontologies (for example GeoSPARQL), so as to be more easily shared and reused, because the quality of the ontology and the project in its entirety resides in its widespread use, in order to become a benchmark for the projects that link to the geographical description

    Probing neutralino properties in minimal supergravity with bilinear R-parity violation

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    Supersymmetric models with bilinear R-parity violation can account for the observed neutrino masses and mixing parameters indicated by neutrino oscillation data. We consider minimal supergravity versions of bilinear R-parity violation where the lightest supersymmetric particle is a neutralino. This is unstable, with a large enough decay length to be detected at the CERN Large Hadron Collider. We analyze the Large Hadron Collider potential to determine the lightest supersymmetric particle properties, such as mass, lifetime and branching ratios, and discuss their relation to neutrino properties

    Thread on testbeds

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    This deliverable presents a set of possible scenarios in which personalization plays a fundamental role in the Semantic Web. These scenarios have been collected with the contribution of many partners of the working group A3, and have then been analysed with two aims. First of all, we have identified the key concepts of personalization scenarios, and subsequently we have analysed the currently available tools and languages supplied by the (Semantic) Web in order to define a set of requirements to be passed to the other working groups of the network.European Commissionpeer-reviewe

    Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model.

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    Background/Aims: Diabetes type 2, metabolic syndrome or non-alcoholic fatty liver disease are insulin resistance-related metabolic disorders, which lack a better prognosis before their full establishment. We studied the importance of the intracellular scaffold protein integrin linked kinaes (ILK) as a key modulator in the initial pathogenesis and the early progression of those insulin resistance- related disorders. Methods: Adult mice with a global transgenic downregulation of ILK expression (cKD-ILK) and littermates without that depletion (CT) were fed with either standard (STD) or high fat (HFD) diets during 2 and 6 weeks. Weights, blood glucose and other systemic biochemical parameters were determined in animals under fasting conditions and after glucose or pyruvate intraperitoneal injections to test their tolerance. In RNA or proteins extracted from insulin-sensitive tissues, we determined by reverse transcription?quantitative PCR and western blot the expression of ILK, metabolites transporters and other metabolism and inflammatory markers. Glucose uptake capacity was studied in freshly isolated tissues. Results: HFD feeding was able to early and progressively increase glycaemia, insulinemia, circulating glycerol, body weight gain, liver-mediated gluconeogenesis along this time lapse, but cKD-ILK have all these systemic misbalances exacerbated compared to CT in the same HFD time lapse. Interestingly, the tisular expression of ILK in HFD-fed CT was dramatically downregulated in white adipose tissue (WAT), skeletal muscle and liver at the same extent of the original ILK downregulation of cKD-ILK. We previously published that basal STD-fed cKD-ILK compared to basal STD-CT have different expression of glucose transporters GLUT4 in WAT and skeletal muscle. In the same STD-fed cKD-ILK, we observed here the increased expressions of hepatic GLUT2 and WAT pro-inflammatory cytokines TNF-? and MCP-1. The administration of HFD exacerbated the expression changes in cKD-ILK of these and other markers related to the imbalanced metabolism observed, such as WAT lipolysis (HSL), hepatic gluconeogenesis (PCK-1) and glycerol transport (AQP9). Conclusion: ILK expression may be taken as a predictive determinant of metabolic disorders establishment, because its downregulation seems to correlate with the early imbalance of glucose and glycerol transport and the subsequent loss of systemic homeostasis of these metabolites.Instituto de Salud Carlos III-ISCIIIComunidad de MadridFondo Europeo de Desarrollo Regional-FEDERInstituto Ramon y Cajal de Investigación Sanitária-IRYCISFundación Renal Iñigo Álvarez de Toledo-FRIA
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